Midwest Research Swine
- Human size – particularly miniature pigs
- Physiology similar to humans
- Large litter sizes
- Cloning and transgenic technology well-advanced
- Numerous well defined cell lines
- Similar disease progression
- metabolic, e.g. obesity and heart disease
- infectious diseases – numerous organisms cause infections across species
- Ability to deliberately time studies and collect repeated and, at kill, detailed tissue samples
- High sequence and chromosome structure homology with humans
- Improving genomic and proteomic tool
Lunney JK. Advances in Swine Biomedical Model Genomics. Int J Biol Sci 2007; 3:179-184.
The swine has been used as a major mammalian model for human studies because of the similarity in size and physiology, and in organ development and disease progression. The pig model allows for deliberately timed studies, imaging of internal vessels and organs using standard human technologies, and collection of repeated peripheral samples and, at kill, detailed mucosal tissues. The ability to use pigs from the same litter, or cloned or transgenic pigs, facilitates comparative analyses and genetic mapping. The availability of numerous well defined cell lines, representing a broad range of tissues, further facilitates testing of gene expression, drug susceptibility, etc. Thus the pig is an excellent biomedical model for humans. For genomic applications it is an asset that the pig genome has high sequence and chromosome structure homology with humans. With the swine genome sequence now well advanced there are improving genetic and proteomic tools for these comparative analyses. The review will discuss some of the genomic approaches used to probe these models. The review will highlight genomic studies of melanoma and of infectious disease resistance, discussing issues to consider in designing such studies. It will end with a short discussion of the potential for genomic approaches to develop new alternatives for control of the most economically important disease of pigs, porcine reproductive and respiratory syndrome (PRRS), and the potential for applying knowledge gained with this virus for human viral infectious disease studies
Midwest Research Swine prides itself in offering high-quality, affordable research swine to the biomedical research industry.
Swine have served as an important biomedical model for decades and some of the best examples of the impact of swine as a biomedical model are found with atherosclerosis and diabetes, diseases that are increasingly important today as the US faces major problems with obesity. Emerging technologies of xenograft and allograft, decellularization and recellularization are now using porcine models because of their physiological and anatomical similarities to human organs and tissue.
Monitoring the continuing demand for their only product – biomedical swine – Midwest Research Swine has increased its number of facilities, expanding their capacity to provide pigs that exceed national SPF requirements and are incomparable in quality to other providers. Our High Health Status Herds™ are durable, docile and readily available to the biomedical research community.
In 1997, Midwest Research Swine established an isolated
High Health Status Herd™
to target the emerging technologies of the biomedical industry
- draws on more than 50 years’ experience dealing with universities, research institutes, biomedical and well-established medical companies.
- is highly-recommended by our customers
- is only in the business of providing swine for biomedical use.
- has access to both air and truck transportation
- is a member of AALAS
We work closely with individual investigators to meet specific research requirements and deliver swine that come exclusively from our High Health Status Herd™.